The present invention relates to a pharmaceutical composition for the treatment of diseases involving cell proliferation. Furthermore, the ratio which gives a synergistic effect and cumulative, present invention provides a compound of formula (I) [Formula 1] (Wherein, R 5 and 3, R 4 groups L, R 1, R 2, R has the meanings given in the specification and claims) Acid addition pharmacologically acceptable salts thereof optionally also the form of mixtures of these tautomers, racemates, enantiomers, and diastereomers (required, solvates, hydrates of the compounds 1, including co-treatment with radiotherapy and simultaneous administration of the active compound in an effective amount 2) and / or may be in the form of a prodrug derivative or polymorph, of the physiologically functional, the method of treating a disease, and on the combined use of radiation therapy and an active compound 2 or an effective amount of / as compound 1 of formula (I) for the preparation of a pharmaceutical combination preparation.本発明は細胞増殖を伴う疾患の治療のための医薬組成物に関する。また、本発明は累積的かつ相乗的効果を与える比の、式(I)【化1】(式中、基L、R1、R2、R3、R4及びR5は請求の範囲及び明細書に示された意味を有する)の化合物1(必要によりその互変異性体、ラセミ体、鏡像体、ジアステレオマー及びこれらの混合物の形態、また必要によりこれらの薬理学上許される酸付加塩、溶媒和物、水和物、多形、生理学上機能性の誘導体又はプロドラッグの形態であってもよい)、及び有効量の活性化合物2の同時投与及び/又は放射線療法との同時治療を含む、前記疾患の治療方法、及び医薬組み合わせ製剤の製造のための式(I)の化合物1と有効量の活性化合物2及び/又は放射線療法の組み合わされた使用に関する。
