BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC.
发明人:
申请号:
EP13710937.7
公开号:
EP2822930B1
申请日:
2013.03.04
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the &bgr;-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of &bgr;-amyloid aggregates.