BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS INC
发明人:
BUKHTIYAROV YURI,DORNERCIOSSEK CORNELIA,LALA DEEPAK S
申请号：
AP201407900
公开号：
AP201407900A0
申请日:
2013.03.04
申请国别(地区):
AP
年份:
2014
代理人:
摘要：
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the &bgr；-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of &bgr；-amyloid aggregates.
