YURI BUKHTIYAROV,SALVACION CACATIAN,LAWRENCE WAYNE DILLARD,CORNELIA DORNER-CIOSSEK,KLAUS FUCHS,LANQI JIA,DEEPAK S LALA,ANGEL MORALES-RAMOS,GEORGE RAST,JONATHAN REEVES,SURESH B SINGH,SHANKAR VENKATRAMA
申请号：
AP2014007900
公开号：
AP4029A
申请日:
2013.03.04
申请国别(地区):
AP
年份:
2017
代理人:
摘要：
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the &bgr；-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of &bgr；-amyloid aggregates.
