TISSUE REGENERATION, INC.;TRUSTEES OF TUFTS COLLEGE
发明人:
ALTMAN, GREGORY H.,KAPLAN, DAVID L.,HORAN, REBECCA L.,HORAN, DAVID
申请号：
CA2467195
公开号：
CA2467195C
申请日:
2002.11.15
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly ananterior cruciate ligament, ex-vivo for implantation into a recipient in needthereof. The invention further provides the novel silk-fiber-based matrixwhich is seeded with pluripotent cells that proliferate and differentiate onthe matrix to form a ligament or tendon ex vivo. Also disclosed is abioengineered ligament comprising the silk-fiber-based matrix seeded withpluripotent cells that proliferate and differentiate on the matrix to form theligament or tendon. A method for producing a ligament or tendon ex vivocomprising the novel silk-fiber-based matrix is also disclosed.
