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STABILE PARENTERALE NIMOPIDINFORMULIERUNG
专利权人:
Nortic Holdings Inc.
发明人:
KOTTAYIL, S., George,KUMAR, Amresh,SUNTHANKAR, Prasanna,KAVURU, Vimal
申请号:
EP17783039
公开号:
EP3442586A4
申请日:
2017.04.12
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.
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