VEHRING, REINHARD,LECHUGA-BALLESTEROS, DAVID,MILLER, DANFORTH P.
申请号：
CA2523475
公开号：
CA2523475C
申请日:
2004.05.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A method of preparing a pharmaceutical formulation comprises providing asolution comprising a first solvent, a second solvent, an active agent, and anexcipient. The second solvent is less polar than the first solvent and theexcipient is more soluble in water than the active agent. The first and secondsolvents are removed from the solution to produce particles comprising theactive agent and the excipient. In one version, the excipient comprises anamino acid and/or a phospholipid. A pharmaceutical formulation made by aversion of the invention comprises particles comprising an active agent and anexcipient which at least partially encapsulates the active agent, wherein theexcipient is more soluble in water than the active agent. An alcoholic aqueoussolution containing a drug, which is preferably water insoluble, an amino acidand/or a phospholipid is spray dried.
