Methods and compositions for increasing alpha-iduronidase activity in the CNS

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专利权人:

ArmaGen Technologies; Inc.

发明人:

PARDRIDGE, William M.,BOADO, Ruben J.

申请号：

AU2013206657

公开号：

AU2013206657A1

申请日:

2013.07.03

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013206657A120130718.pdf#####ABSTRACT Provided herein are methods and compositions for treating a subject suffering from a deficiency in a-L-Iduronidase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an a-L-Iduronidase. A therapeutically effective systemic dose is based on the specific CNS uptake characteristics of human insulin receptor antibody-a-L-Iduronidase fusion antibodies as described herein. -484478550_1 (GHMatters) P83171.AU.1

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中国工程科技知识中心

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http://www.ckcest.cn/home/