Methods and compositions for increasing enzyme activity in the CNS

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专利权人:

ArmaGen Technologies; Inc

发明人:

Pardridge, William M.,Boado, Ruben J.

申请号：

AU2014293626

公开号：

AU2014293626A1

申请日:

2014.05.19

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Provided herein are methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). The bifunctional fusion antibodies provided herein comprise an antibody to an endogenous blood brain barrier (BBB) receptor and an enzyme deficient in mucopolysaccharidosis III (MPS-III). The fusion antibodies provided herein comprise N- sulfoglucosamine sulfohydrolase (SGSH), alpha-N-acetylgulcosaminidase (NAGLU), heparin-alpha- glucosaminide N-acetyltransferase (HGSNAT), or N-acetylglucosamine-6-sulfatase (GNS). The methods of treating an enzyme deficiency in the CNS comprise systemic administration of a fusion antibody provided herein.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/