Methods and compositions for increasing alpha-iduronidase activity in the CNS

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专利权人:

Inc.;ArmaGen Technologies

发明人:

PARDRIDGE, William M.,BOADO, Ruben J.

申请号：

AU2016202625

公开号：

AU2016202625A1

申请日:

2016.04.26

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016202625A120160519.pdf#####ABSTRACT Provided herein are methods and compositions for treating a subject suffering from a deficiency in a-L-Iduronidase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an a-L-Iduronidase. A therapeutically effective systemic dose is based on the specific CNS uptake characteristics of human insulin receptor antibody-at-LIduronidase fusion antibodies as described herein. 7671816_1 (GHMatters) P83171.AU.2

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/