VYBYL HOLDINGS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
CALLMANN, CASSANDRA E.,THOMPSON, MATTHEW P.,LEGUYADER, CLARE L. M.,GIANNESCHI, NATHAN C.,BERTIN, PAUL A.
申请号：
CA2998528
公开号：
CA2998528A1
申请日:
2016.09.21
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.
