Vybyl Holdings, Inc.;The Regents of the University of California
发明人:
Callmann, Cassandra E.,Thompson, Matthew P.,Leguyader, Clare L. M.,Gianneschi, Nathan C.,Bertin, Paul A.
申请号：
AU2016326392
公开号：
AU2016326392A1
申请日:
2016.09.21
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.
