The Regents of the University of California;Vybyl Holdings, Inc.
发明人:
Cassandra E. Callmann,Matthew P. Thompson,Nathan C. Gianneschi,Clare L.M. LeGuyader,Paul A. Bertin
申请号：
US16357502
公开号：
US20190381179A1
申请日:
2019.03.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.
