The Government of the United States of America; as represented by the Secretary of the Navy
发明人:
Okhil Nag,Jawad Naciri,Jeff Erickson,James B. Delehanty
申请号：
US16793191
公开号：
US20200215190A1
申请日:
2020.02.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A liquid crystal nanoparticle (LCNP)-based system allows for the encapsulation and targeted delivery of Zinc (II) phthalocyanine (ZnPC) to the plasma membrane bilayer of living cells for photodynamic therapy (PDT). The formulation comprises LCNPs that are loaded in their hydrophobic core with perylene (PY) and ZnPC. In embodiments, the LCNP surface is functionalized with Poly(ethylene glycol)-cholesterol conjugates (PEG-Chol) and/or another material enabling targeting the particle to the cellular membrane. This can improve cell killing via reactive oxygen species (ROS) generation as it allows for the localized ROS-mediated peroxidation of lipids in the membrane bilayer.
