FREYNE, EDDY JEAN E., JANSSEN PHARMACEUTICA N.V.,WILLEMS, MARC, JANSSEN PHARMACEUTICA N.V.,EMBRECHTS, WERNER C. J., JANSSEN PHARMACEUTICA N.V,VAN EMELEN, KRISTOF, JANSSEN PHARMACEUTICA N.V.,VAN BRANDT
申请号:
DK05819148
公开号:
DK1824856T3
申请日:
2005.12.08
申请国别(地区):
DK
年份:
2014
代理人:
摘要:
The present invention is drawn to 2,4 (4,6) pyrimidine derived macrocyclcs, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.