Marc Willems;Sven Franciscus Anna Van Brandt;Eddy Jean Edgard Freyne;Werner Constant Johan Embrechts;Kristof Van Emelen;Frederik Jan Rita Rombouts
发明人:
Eddy Jean Edgard Freyne,Marc Willems,Werner Constant Johan Embrechts,Kristof Van Emelen,Sven Franciscus Anna Van Brandt,Frederik Jan Rita Rombouts
申请号：
US11720681
公开号：
US08148388B2
申请日:
2005.12.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is drawn to 2,4 (4,6) pyrimidine derived macrocyclcs, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.
