17beta-ALKYL-17alpha-OXY-ESTRATRIENES

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专利权人:

BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

BOHLMANN, ROLF,HEINRICH, NIKOLAUS,HUBNER, JAN,KETTSCHAU, GEORG,KUNZER, HERMANN,LIENAU, PHILIP,GERISCH, MICHAEL,LANG, DIETER,DENNER, KARSTEN,SANDER, MICHAEL,HOFFMANN, JENS,WINTERMANTEL, TIM,KOHR, SILKE

申请号：

NZ59682410

公开号：

NZ596824A

申请日:

2010.05.26

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]pentyl]oestra-1,3,5(10)-triene-3,17?-diol； and 11?-fluoro-17?-methyl-7?-[5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl]oestra- 1,3,5(10)-triene-3,17?-diol.

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