Fused tricyclic compounds as raf kinase inhibitors

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专利权人:

BEIGENE LTD.

发明人:

WANG SHAOHUI,ZHANG GUOLIANG,ZHOU CHANGYOU

申请号：

NZ62406811

公开号：

NZ624068A

申请日:

2011.12.31

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are fused tricyclic compounds of the general formula I, wherein the variables are as defined in the specification. Examples of the compounds include (±)-exo-5-((1(1H-benzo[d]imidazol-2-yl)-1,1a,6,6a-tetrahydrocyclopropa[a]inden-3-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one and (±)-exo-5-((1-(5-fluoro-6-methyl-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cylopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one. The compounds are inhibitors of RAF kinase. The compounds may be useful in the treatment of cancer.

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