Van Lommen, Guy Rosalia Eugeen,Buyck, Christophe Francis Robert Nestor,Berwaer, Monique Jenny Marie,Boeckx, Gustaaf Maria,Davidenko, Petr Vladimirivich,De Waepenaert, Katharina Antonia Germania J.M.,C
申请号：
AU2008258487
公开号：
AU2008258487B2
申请日:
2008.06.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to a DGAT inhibitor of formula (I): including any stereochemicallyisomeric form thereof, wherein A represents CH or N； the dotted line representsan optional bond in case A represents a carbon atom； X represents -C(=O)-； -O-C(=O)-；-C(=O)-C(=O)-； -NR-C(=O)-； -Z-C(O)-； -Z-NR-C(=O)-；-C(=O)-Z-； -NR-C(=O)-Z-； -S(=O)p-； -C(=S)-；-NR-C(=S)-； -Z-C(=S)-； -Z-NR-C(=S)-；-C(=S)-Z1-； -NR-C(=S)-Z-； Y represents NR-C(=0)-Z-； -NR-C(=0)-Z-NR-； -NR-C(=0)-Z-NR-C(=0)-；-NR-C(=0)-Z-NR-C(=0)- O-； -NR-C(=0)-Z-0-；-NR-C(=0)-Z-0-C(=0)-； -NR-C(=0)-Z-C(=0)-；-NR-C(=0)-Z-C(=0)-0-； -NR-C(=0)-0-Z-C(=0)-；-NR-C(=0)-0-Z-C(=0)-0-； -NR-C(=O)-O-Z-O-C(=O)-；-NR-C(=O)-Z-C(=O)-NR-； -NR-C(=O)-Z-NR-C(=0)-NR-； -C(=O)-Z-； -C(=O)-Z-O-； -C(=0)-NR-Z-；-C(=0)-NR-Z-0-； -C(=0)-NR-Z-C(=0)-0-；-C(=0)-NR-Z-0-C(=0)-； -C(=0)-NR-0-Z-；-C(=O)- NR-Z-NR-； -C(=0)-NR-Z-NR-C(=0)-；-C(=0)-NR-Z-NR-C(=0)-0-； Rrepresents Calkyl optionally substituted with cyano, Calkyloxy,Calkyl-oxyCalkyloxy, CCy cloalkylor aryl； Calkenyl； Calkynyl； Ccycloalkyl；adamantanyl； aryl； arylCalkyl； Het；or HetCalkyl； provided that when Y represents -NR-C(=O)-Z-；-NR-C(=0)-Z-NR； -NR-C(=O)-Z-C(=O)-NR-； -C(=O)-Z-； -NR-C(=0)-Z-NR-C(=0)-NR-；-C(=O)-NR-Z-； -C(=O)-NR- O-Z-；or -C(=0)-NR-Z-NR-； then R mayalso represent hydrogen； R represents hydrogen, Calkyl,Calkenyl or R； provided that if X represents -O-C(=O)-,then R represents R； and provided that is excluded； a N-oxidethereof, a pharmaceutically acceptable salt thereof or a solvate thereof. Theinvention further relates to methods for preparing such compounds, pharmaceuticalcompositions comprising said compounds as well as the use as a medicine of saidcompounds.
