A detachable prosthodontic device includes an abutment, a suprastructure, and a screw. The abutment includes a hollow chamber. A screw hole is arranged on an abutment wall of the hollow chamber. The suprastructure is provided with a receiving region and an inner surface surrounding the receiving region. The screw includes a screw head and a screw rod. The screw head includes a contact member and a guiding member. When the screw is mounted in the screw hole, a portion of the screw head protrudes outward from an outer surface of the hollow chamber. When the suprastructure is sleeved onto the abutment, partial area of the outer surface of the hollow chamber contacts with partial area of the inner surface of the suprastructure, and the screw head supports an opposing side of the inner surface to apply a force onto the inner surface to thereby retain the suprastructure onto the abutment.