CARITAS ST. ELIZABETH MEDICAL CENTER OF BOSTON,INC.;LOSORDO, DOUGLAS, W.
发明人:
LOSORDO, DOUGLAS, W.
申请号:
WO2006US41545
公开号:
WO2007050648(A3)
申请日:
2006.10.24
申请国别(地区):
世界知识产权组织国际局
年份:
2009
代理人:
摘要:
The invention generally provides methods and compositions for modulating TNFR2 p75 receptor expression for the treatment or prevention of ischemia in a subject. In one embodiment, the invention enhances collateral vessel development and mobilization of endothelial progenitor cells (EPCs) from bone marrow by increasing p75 TNFR2 signaling in a cell of the subject.