Andrés Pablo Montefeltro,Gabriel Alvarado Urbina,Analia Bortolozzi Biassoni,Francesc Artigas Pérez,Miquel Vila Bover,Maria del Carmen Carmona Orozco
申请号：
US14803811
公开号：
US10125363B2
申请日:
2015.07.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides a conjugate comprising (i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (DAT), serotonin transporter (SERT) or a norepinephrine transporter (NET) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is α-synuclein or the mRNA encoding α-synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes.
