CARMONA OROZCO, MARIA DEL CARMEN,MONTEFELTRO, ANDRES PABLO,ALVARADO, GABRIEL G.,VILA BOVER, MIQUEL,BORTOLOZZI, ANALIA,ARTIGAS PEREZ, FRANCESC
申请号：
CA2890112
公开号：
CA2890112A1
申请日:
2013.10.25
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides a conjugate comprising(i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (DAT), serotonine transporter (SERT) or a norepinephrine transporter (NET) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is a-synuclein or the mRNA encoding a-synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes.
