CARMONA OROZCO MARIA DEL CARMEN,MONTEFELTRO ANDRÉS PABLO,ALVARADO GABRIEL G,VILA BOVER MIQUEL,BORTOLOZZI ANALIA,ARTIGAS PÉREZ FRANCESC
申请号：
IN4452/DELNP/2015
公开号：
IN2015DN04452A
申请日:
2015.05.25
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The invention provides a conjugate comprising(i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (DAT) serotonine transporter (SERT) or a norepinephrine transporter (NET) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is a synuclein or the mRNA encoding a synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus for the treatment of diseases which require a down regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes.
