DÉRIVÉS D'ÉTHYNYLE COMME MODULATEURS ALLOSTÉRIQUES POSITIFS DE MGLUR5

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专利权人:

F.HOFFMANN-LA ROCHE AG

发明人:

申请号：

EP12718153.5

公开号：

EP2702051B1

申请日:

2012.04.23

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3&prime；, R4, R4&prime；, R5, R6, R6&prime；, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.

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