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ETHYNYL DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MGLUR5
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
JAESCHKE GEORG,JAESCHKE Georg,JOLIDON SYNESE,JOLIDON Synese,LINDEMANN LOTHAR,LINDEMANN Lothar,STADLER HEINZ,STADLER Heinz,VIEIRA ERIC,VIEIRA Eric
申请号:
SI201230199
公开号:
SI2702051T1
申请日:
2012.04.23
申请国别(地区):
SI
年份:
2015
代理人:
摘要:
The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3&prime, R4, R4&prime, R5, R6, R6&prime, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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