JAESCHKE, GEORG,JOLIDON, SYNESE,LINDEMANN, LOTHAR,STADLER, HEINZ,VIEIRA, ERIC
申请号：
PL12718153
公开号：
PL2702051T3
申请日:
2012.04.23
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3&prime；, R4, R4&prime；, R5, R6, R6&prime；, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
