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Stable dosage form of etidronate-cytarabine conjugate, and use thereof
专利权人:
OSTEROS BIOMEDICA LTD.
发明人:
申请号:
IL25971218
公开号:
IL259712D0
申请日:
2018.05.30
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
The invention relates to the field of medicine and pharmaceuticals and particularly to a novel dosage form of an antitumour preparation, which ensures the hydrolytic and physical stability of said preparation, as well as to a method for producing a dosage form of this type. The present stable dosage form is a lyophilisate comprising an etidronate-cytarabine conjugate or a pharmaceutically acceptable salt thereof, and a stabiliser which is a divalent metal salt, in a molar ratio of stabiliser to conjugate of 1:1 to 20:1. A dosage form of this type ensures the hydrolytic and physical stability of the conjugate during long-term storage, and the stability of solutions of the conjugate for parenteral administration during clinical use of same.
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