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FORME GALÉNIQUE STABILISÉ D'UN CONJUGUÉ D'ÉTHYDRONATE AVEC LE CITRABINE ET SON UTILISATION
专利权人:
Osteros Biomedica Ltd.
发明人:
申请号:
EP16871137.2
公开号:
EP3384900A1
申请日:
2016.11.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The invention relates to the field of medicine and pharmaceuticals and particularly to a novel dosage form of an antitumor preparation, which ensures the hydrolytic and physical stability of said preparation, as well as to a method for producing a dosage form of this type. The stable dosage form is a lyophilizate comprising an etidronate-cytarabine conjugate or a pharmaceutically acceptable salt thereof, and a stabilizer, which is a divalent metal salt, in a molar ratio of stabilizer to conjugate of 1:1 to 20:1. A dosage form of this type ensures the hydrolytic and physical stability of the conjugate during long-term storage, and the stability of solutions of the conjugate for parenteral administration during clinical use.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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