The invention provides a chemical entity of Formula (I) wherein R R R Y and n have any of the values described herein and compositions comprising such chemical entities methods of making them and and their use in a wide range of methods including metabolic and reaction kinetic studies detection and imaging techniques and radioactive treatments and therapies including inhibiting MAO and MAO B selectively enhancing neuronal plasticity treating neurological disorders providing neuroprotection treating a cognitive or motor impairment associated with a CNS disorder enhancing the efficiency of cognitive and motor training providing neurorecovery and neurorehabilitation enhancing the efficiency of non human animal training protocols and treating treating peripheral disorders (including obesity diabetes and cardiometabolic disorders) and their associated co morbidities.
