PHARMACEUTICAL COMPOSITION COMPRISING SHIKONIN DERIVATIVES FROM LITHOSPERMUM ERYTHRORHIZON FOR TREATING OR PREVENTING DIABETES MELLITUS AND THE USE THEREOF
JIN-DO COUNTY;PARK, JI HO;KIM, SUN YEOU;KANG, TONG HO;HWANG, EUN JU;KANG, CHUL HOON
发明人:
PARK, JI HO,KIM, SUN YEOU,KANG, TONG HO,HWANG, EUN JU,KANG, CHUL HOON
申请号：
WO2006KR05414
公开号：
WO2008072799(A9)
申请日:
2006.12.12
申请国别(地区):
世界知识产权组织国际局
年份:
2009
代理人:
摘要：
The present invention relates to a composition comprising shikonin compounds, especially, isobutyryl shikonin, ??,??-dimethylacryl shikonin, isovaleryl shikonin, and a-methyl-n-butyryl shikonin as an active ingredient for the prevention and treatment of diabetes mellitus and the use thereof. The composition of the present invention showed stimulating effect on the release of insulin in the beta cell of the pancreas due to inhibitory effect on K ATP ion channel of beta cell in pancreas together with promoting effect on the increase of calcium concentration. Therefore, it can be used as the therapeutics, health functional food or food additive for treating and preventing diabetes mellitus.
