Katholieke Universiteit Leuven;University College Cardiff Consultants Limited
发明人:
McGuigan, Christopher,Perrone, Plinio,Neyts, Johan
申请号：
AU2007323220
公开号：
AU2007323220B2
申请日:
2007.11.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Phosphoramidate derivatives of nucleoside compounds of formula I derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the β-2' position with methyl and the phosphoramidate group, suitably comprises 1-naphthyl linked by -O- to the P atom.
