NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS

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专利权人:

发明人:

MCGUIGAN, CHRISTOPHER,NEYTS, JOHAN,PERRONE, PLINIO

申请号：

MYPI 20091944

公开号：

MY145856A

申请日:

2007.11.23

申请国别(地区):

MY

年份:

2012

代理人:

摘要：

PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS OF FORMULA 1 DERIVED FROM BASES SUCH AS ADENINE AND GUANINE HAVE ENHANCED THERAPEUTIC POTENCY IN PARTICULAR, ENHANCED POTENCY WITH RESPECT TO THE PROPHYLAXIS OR TREATMENT OF A VIRAL INFECTION SUCH AS HEPATITIS C VIRUS. THE GLYCOSIDE MOIETY OF THE NUCLEOSIDE COMPOUND IS SUITABLY SUBSTITUTED AT THE ß2 POSITION WITH METHYL AND THE PHOSPHORAMIDATE GROUP, SUITABLY COMPRISES 1-NAPHTHYL LINKED BY -O- TO THE P ATOM.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/