Disclosed is a self-destruction injection safety needle, comprising an injection needle (1) including a barrel (11, 11a, 11b, 11c) and a pusher (12, 12a, 12b, 12e, 12f) provided at one end of the barrel (11, 11a, 11b, 11c) in a telescopic manner. The pusher (12, 12a, 12b, 12e, 12f) is provided with a soft pusher sealing sleeve (2, 2a) and a pusher piston portion (121). A barrel opening portion (111) and a barrel jointing portion (112) are formed on the barrel (11, 11a, 11b, 11c), and a barrel liquid outlet (113) is formed at an end thereof provided with the barrel jointing portion (112). The pusher (12, 12a, 12b, 12e, 12f) is provided with a pusher joint (122, 122a, 122b, 122e, 122f) and a joint jointing portion (13, 13a, 13b). The injection needle (1) is provided with a self-destruction combination device (3, 3a, 3b, 3e, 3f). The self-destruction combination device (3, 3a, 3b, 3e, 3f) includes a self-destruction positioning assembly (33, 33a, 33b) and a self-destruction engaging assembly (32, 32a, 32b). The self-destruction engaging assembly (32, 32a, 32b) includes at least one self-destruction engaging rod body (322, 322a, 322b), at least one self-destruction engaging rod hooking member (323, 323b), a self-destruction restraining portion (325, 325a, 325b) and a self-destruction connecting body (321, 321a, 321b). The self-destruction combination device (3, 3a, 3b, 3e, 3f) is further provided with a self-destruction piston portion (31, 31b) and a self-destruction blocking member (311, 311a, 311b). Thus, after being used, the self-destruction combination device (3, 3a, 3b, 3e, 3f) is fixedly retained in the barrel (11, 11a, 11b, 11c) to seal the liquid outlet (113), such that a state is formed in which the self-destruction combination device cannot be removed, thereby achieving the effects of active jointing self-destruction and detachment self-destruction.L'invention concerne une aiguille d'injection de sécurité, autodestructive, comprenant une aiguille d'injection