Use of peptides and other biological agents for fabrication of transistors, field effect transistors, and components thereof. An intermediate component for use in fabrication of a field effect transistor, the component comprising at least two of the following transistor elements: (i) source, (ii) drain, (iii) channel, (iv) gate, and (v) dielectric, wherein the at least two elements are combined by a biological agent comprising at least two binding structures, wherein each of the binding structures is bound to one of the at least two elements. The channel can be a nanowire or a nanotube which is surrounded by a high-K dielectric material, which is further surrounded by a metal gate layer. The biological agent can be a bifunctional peptide which binds dielectric to channel or binds dielectric to gate materials.