CYSTEINE ENGINEERED ANTIGEN-BINDING MOLECULES

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专利权人:

MERCK PATENT GMBH;UNIVERSITÄT FÜR BODENKULTUR WIEN

发明人:

Gordana WOZNIAK-KNOPP,Florian RÜKER,Gerhard STADLMAYR,Jakub RYBKA,Nicolas RASCHE,Stephan DICKGIESSER

申请号：

US16650124

公开号：

US20200277399A1

申请日:

2018.10.03

申请国别(地区):

US

年份:

2020

代理人:

摘要：

A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain； and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.

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