Bart DE GOEIJ,Joost MELIS,Tom VINK,Hendrik TEN NAPEL,Esther BREIJ,David SATIJN,Paul PARREN
申请号：
US16072437
公开号：
US20190352423A1
申请日:
2017.02.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−；9 and 10−；8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
