Disclosed herein are methods for removing spores from skin, the method including dispensing an effective amount of a composition into or onto an article, wherein the composition includes water and from about 0.04 wt % to about 4 wt % polymeric cationic antimicrobial, nonionic antimicrobial or combinations thereof; contacting a skin surface with the composition; mechanically acting on the skin surface for at least one (1) second while the skin surface is in the presence of the composition; and removing at least a portion of the composition from the surface of the skin, wherein removing the composition also removes spores from the skin surface.