您的位置: 首页 > 农业专利 > 详情页

SYSTEM AND METHOD FOR MULTIPHASIC RELEASE OF GROWTH FACTORS
专利权人:
ИНДЬЮС БАЙОЛОДЖИКС ИНК. (CA)
发明人:
КЛОУКИ Кэмерон М.Л. (CA),ПИЛ Шон А.Ф. (CA)
申请号:
RU2013150080/15
公开号:
RU2013150080A
申请日:
2012.04.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The composition of the multiphase release of growth factors at the site of application, containing: - a delivery vehicle containing at least one first growth factor; and - a carrier containing at least one second growth factor; where: - the delivery vehicle is configured to release at least one first growth factor in the initial release profile for the first period of time; - the carrier is configured to release, according to at least one second growth factor in the sustained release profile for a second period of time. 2. The composition of claim 1, wherein the delivery vehicle comprises a polymer. The composition of claim 2, wherein the polymer is a reverse phase polymer or a block copolymer. The composition of claim 3, wherein the polymer is poloxamer. The composition of claim 4, wherein the polymer is poloxamer 407.6. The composition of claim 1, wherein the carrier comprises a plurality of particles dispersed in a polymer matrix, and where the particles contain at least one second growth factor on their surface. The composition of claim 6, wherein the particles comprise calcium phosphate particles. The composition of claim 6, wherein the polymer matrix comprises polylactic acid (PLA) or a copolymer of lactic and glycolic acids (PLGA). The composition of claim 1, wherein the first time period covers hours or days. The composition of claim 9, wherein the second time period covers a day or weeks. The composition of claim 1, wherein at least one first growth factor and at least one second growth factor are the same. The composition of claim 1, wherein the at least one first growth factor and the at least one second growth factor are different. The composition according to claim 1, where the first and second growth factors are1. Композиция многофазного высвобождения факторов роста на участке применения, содержащая:- средство доставки, содержащее, по меньшей мере, один первый фактор роста; и- носитель, содержащий, по меньшей мере, один второй фактор роста;где:- сре
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充