#$%^&*AU2017200773A120170302.pdf#####1 ABSTRACT 2 A system for multiphasic delivery of at least one growth factor at a treatment site 3 comprises a delivery vehicle for releasing at least one growth factor in an initial release profile 4 and a carrier for releasing at least one growth factor in a sustained release profile. The initial 5 release profile releases at least one growth factor over a period of hours to days, wherein the 6 growth factor is released in a large amount initially, with the remainder being released in 7 progressively lower amounts. The sustained release profile releases at least one growth factor 8 over a period of days to weeks, wherein the growth factor is released at a generally constant 9 amount over such period. The system of the invention is particularly suited for applications on 0 bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least 1 one growth factor.
