The invention provides a hericium powder for delaying functional degeneration of the brain. The hericium powder has a particle size in a range of 10 micrometers-12 micrometers. In addition, a method of making a hericium powder for delaying functional degeneration of the brain includes steps: providing a hericium powder having D50of 100 micrometers-150 micrometers obtaining a hericium powder having D50of 10 micrometers-12 micrometers by ultrafine grinding technology.本發明係提供一種用於延緩腦部功能性退化的猴頭菇粉末,其具有粒徑D50範圍10微米-12微米。另外,本發明之用於延緩腦部功能性退化的猴頭菇粉末的製造方法,包括步驟:提供具有粒徑D50為100微米-150微米的猴頭菇粉末;藉由超微粉碎技術,得到粒徑D50為10 微米-12微米的猴頭菇粉末。