The present invention closes the fused bicyclic pyrimidine compounds of what formula (I). The present invention also discloses a kind of active method of inhibition aurora kinase and a kind of method with these compound treating cancers.本發明關於式(I)的稠合雙環嘧啶化合物。本發明也公開一種抑制極光激酶活性的方法,以及一種用這些化合物治療癌症的方法。