The present invention relates to the compound of Formulas I-II and its pharmaceutical tautomers, salt or stereoisomer, they are syk and/or jak kinase inhibitor. The invention further relates to the intermediate for preparing this compound with what, the method for preparing these compounds, the Pharmaceutical composition containing these compounds, inhibit syk and/or the active method of jak kinase, the method for inhibition platelet aggregation and prevention or treatment at least partly by syk and/or the method for a variety of diseases of jak kinase activity mediation, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative diseases, thrombosis, allergy, asthma, rheumatoid arthritis, leukaemia or non-Hodgkin lymphoma.本發明涉及式I-II的化合物及其可藥用的互變異構體、鹽或立體異構體，它們爲syk和/或JAK激酶抑制劑。本發明還涉及用於製備這種化合物的中間體、製備這些化合物的方法、含有這些化合物的藥用組合物、抑制syk和/或JAK激酶活性的方法、抑制血小板凝集的方法以及預防或治療至少部分由syk和/或JAK激酶活性介導的多種疾病的方法，例如心血管病、炎性疾病、自身免疫疾病和細胞增殖病症、血栓形成、過敏、哮喘、類風濕性關節炎、白血病或非霍奇金淋巴瘤。
