The present invention relates to 1H- pyrazolo [3,4-d] pyrimidine loop system PI3K δ protein kinase selective depressant, the method for preparing them, comprising they pharmaceutical composition and the method for kinase mediated related disease or illness is treated and/or prevented using them.本發明涉及具有1H‑吡唑并[3,4‑d]嘧啶環系統的PI3K δ蛋白激酶的選擇性抑制劑,製備它們的方法,包含它們的藥物組合物和利用它們治療和/或預防激酶介導的相關疾病或病症的方法。