The present invention includes a method of reducing or inhibiting the kinase activity of normal and mutated FLT3 in a cell or a subject, and the use of such compound for preventing or treating cell proliferative disorder(s) in a subject related to using a compound of the present invention: or pharmaceutically acceptable salt thereof.本發明包括降低或抑制細胞或對象中正常和突變FLT3激酶活性的方法,以及與利用本發明化合物此類化合物在預防或治療對象中細胞增殖性疾病的用途:或其藥學上可接受的鹽。