8S9R-5--8-4--9-1--1H-124--5--89--2H-[432-DE]-37H- CRYSTALLINE 8S9R-5-FLUORO-8-4-FLUOROPHENYL-9-1-METHYL-1H-124-TRIAZOL-5-YL-89-DIHYDRO-2H-PYRIDO[432-DE]PHTHALAZIN-37H-ONE TOSYLATE SALT
The invention, including the crystalline form, (8 S, 9 R) -5- fluoro-8- (4-fluorophenyl) -9- (1-methyl -1 H -1,2,4- triazole 5-yl) 8,9-dihydro -2 H - pyrido [4,3,2- de] phthalazine -3 (7 H) - the on-tosylate salt form, and provides a method of manufacturing do. Further, (8 S, 9 R) -5-fluoro-8- (4-fluorophenyl) -9- (1-methyl -1 H -1,2,4- triazol-5-yl) -8 , 9-dihydro -2 H - pyrido [4,3,2- de] phthalazine -3 (7 H) - and a pharmaceutical composition comprising an on-tosylate salt, treating a disease or condition, such as cancer, to (8 S, 9 R) -5-fluoro-8- (4-fluorophenyl) -9- (1-methyl -1 H -1,2,4- triazol-5-yl) -8, 9-dihydro -2 H - provides a method of using the on-tosylate salt-pyrido [4,3,2- de] phthalazine -3 (7 H).본 발명은, 결정질 형태를 비롯하여, (8S,9R)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1H-1,2,4-트리아졸-5-일)-8,9-디하이드로-2H-피리도[4,3,2-de]프탈라진-3(7H)-온 토실레이트 염 형태들, 및 이의 제조 방법을 제공한다. 또한, (8S,9R)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1H-1,2,4-트리아졸-5-일)-8,9-디하이드로-2H-피리도[4,3,2-de]프탈라진-3(7H)-온 토실레이트 염을 포함하는 약학 조성물과, 암과 같은 질환 또는 병태를 치료하기 위해 (8S,9R)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1H-1,2,4-트리아졸-5-일)-8,9-디하이드로-2H-피리도[4,3,2-de]프탈라진-3(7H)-온 토실레이트 염을 사용하는 방법을 제공한다.
