ДРЕССМАН Марлин Мишелл (US),ЛАЙКАМИЛ Луис Уилльям (US),ПОЛИМЕРОПОУЛОС Михаэл Х. (US)
申请号：
RU2014134552
公开号：
RU2014134552A
申请日:
2013.01.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The method for determining the circadian period (τ) in humans, which is that: a) collect at least one biological sample from the patient’s body during each of several regular collection intervals (CI), using at least two collection series, where the duration each collection series is at least 48 hours； b) if several biological samples are collected during each CI, then all the samples collected in this CI are optionally physically combined, in which case the time point of collection for each o CI； c) quantify (absolute amount or concentration) of melatonin or the indirect melatonin parameter in each of the samples or in the combined samples； d) optionally convert the amount of melatonin or the indirect melatonin parameter at each time point of collection to the production rate； e) expose the amount melatonin or an indirect parameter of melatonin or the rate of production of melatonin or an indirect parameter of melatonin at each time point for collecting an analysis for a patient to simulate a cycle, including i the acrophase, the amount or production of melatonin, or the indirect parameter of melatonin every day； e) fit the obtained acrophase values in series to the model by the method of weighted linear regression to determine τ, where τ = 24 + the slope of the curve. 2. The method of claim 1, wherein in step (e), an analysis is performed based on the cosine function of the amount of melatonin or the indirect parameter of melatonin or the rate of production of melatonin or the indirect parameter of melatonin at each time point of collection to simulate a patient’s cycle, including acrophase, amount or1. Способ определения циркадного периода (τ) у человека, заключающийся в том, чтоа) собирают по меньшей мере один биологический образец из организма пациента в течение каждого из нескольких регулярных интервалов сбора (CI), используя по меньшей мере две серии сбора, где продолжительность каждой серии сбора составляет по меньшей мере 48 ч；б) если собирают несколько
