Disclosed is a preparation method for a caspofungin analog, comprising the steps: (a) a compound as represented in Formula 2 and a strong leaving group 5 are mixed to obtain a compound as represented in Formula 3 (b) the compound as represented in Formula 3 and ethylenediamine are mixed to obtain a compound as represented in Formula 4 and, (c) the compound as represented in Formula 4 is mixed with a hydroxyl protection agent, and then a borane complex is mixed in to obtain a compound as represented in Formula 1.Linvention concerne un procédé de préparation dune caspofungine comprenant les étapes suivantes : a) obtention dun composé de formule 3 moyennant le mélange dun composé à groupe partant fort 5 et un composé de formule 2 b) obtention dun composé de formule 4 moyennant le mélange dun éthylènediamine et dun composé de formule 3 et c) obtention dun composé de formule 1 moyennant le mélange dun agent de protection hydroxyle et dun composé de formule 4, suivi du mélange dun composé de complexe borane.
