HE BINGMING,헤, 빙밍,LI MING,리, 밍,TANG ZHIJUN,탕, 지준,JI XIAOMING,지, 샤오밍
申请号：
KR1020137014782
公开号：
KR1020130118901A
申请日:
2011.11.10
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
Disclosed is a preparation method for caspofungin, comprising the steps: (a) a compound as represented in Formula 2 and a strong leaving group 5 are mixed to obtain a compound as represented in Formula 3 (b) the compound as represented in Formula 3 and ethylenediamine are mixed to obtain a compound as represented in Formula 4 and, (c) the compound as represented in Formula 4 is mixed with a hydroxyl protection agent, and then a borane complex is mixed in to obtain a compound as represented in Formula 1.본 발명에는 카스포펀진의 제조방법이 기재 되었으며, 상기 방법은, (a)화학식 2로 표시된 화합물과 강한 탈리기 화합물 5를 혼합하여 화학식 3으로 표시된 화합물을 얻는 단계, (b)화학식 3으로 표시된 화합물과 에틸렌디아민을 혼합하여 화학식 4로 표시된 화합물을 얻는 단계, (c)화학식 4로 표시된 화합물과 히드록시 보호제를 혼합한 후, 보란(borane) 복합체와 혼합하여 화학식 1로 표시된 화합물을 얻는 단계를 포함한다.
