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GASTROINTESTINAL-PROTECTIVE FORMULATIONS FOR ORAL DELIVERY OF PROTEINS AND PEPTIDES
专利权人:
发明人:
James Blair WEST,Ke SHI
申请号:
US15927977
公开号:
US20190030003A1
申请日:
2018.21.03
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Disclosed herein are processes for formulating a protein or a peptide for oral delivery, the process comprising the steps of: obtaining a powder containing the protein or peptide obtaining an amount of an enteric polymer, wherein the enteric polymer is neutralized so that it is soluble in water optionally obtaining at least one excipient mixing the protein or peptide, the neutralized enteric polymer, and optionally the at least one excipient to obtain a First Dispersion granulating the First Dispersion on a fluidized bed to obtain a Second Dispersion whereby the protein or peptide in the Second Dispersion undergoes less than 50% proteolysis under gastric conditions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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